Plenary
Oliver Kappe, University of Graz
Title: How to handle solids/slurries in flow
C. Oliver Kappe is Professor of Chemistry at the University of Graz (Austria) and Scientific Director of the Center of Continuous Flow Synthesis and Processsing (CCFLOW) at RCPE GmbH. For the past decade the focus of his research has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and manufacturing, employing a number of different enabling and process intensification strategies.
Ken-Ichiro Sotowa, Kyoto University
Title: Modular and Flexible IoT-Based Automated Experimental Systems
Ken-Ichiro Sotowa is a professor of chemical engineering specializing in continuous flow processes and laboratory automation. After earning his MSc(Eng) and PhD at the University of Leeds under the supervision of Prof. C. McGreavy, he conducted research on microreaction technologies at Kyushu and Tokushima Universities. Since his appointment as professor at Kyoto University in 2019, he has focused on developing flexible automated experimental systems. He served as Head of the Subdivision of Micro Chemical Processes Engineering (2014–2016) and Editor-in-Chief of the Journal of Chemical Engineering of Japan (2021–2023).
Timothy Noel, University of Amsterdam
Title:
Timothy Noël studied Chemical Engineering in Ghent and obtained his PhD in synthetic organic chemistry at the University of Ghent. Next, he worked at the Massachusetts Institute of Technology (MIT) as a Fulbright Postdoctoral Fellow with Professor Stephen L. Buchwald. In 2012 he became an assistant professor at Eindhoven University of Technology where he was appointed associate professor in 2017. Currently, he is a Full Professor at the University of Amsterdam and Chair of Flow Chemistry at the Van ‘t Hoff Institute for Molecular Sciences. His research interests are synthetic organic chemistry and technology, and especially the delicate synergy between these two fields. He is the editor-in-chief of Journal of Flow Chemistry.
Invited Speakers
Takashi Ohshima, Kyushu University
Title: Development of Solid-Supported Catalysts for Flow Ester Exchange Reactions and Continuous Flow Synthesis of (–)-α-Kainic Acid
Takashi Ohshima was born in Ehime, Japan, in 1968. He received B. Sc. from Faculty of Pharmaceutical Sciences, The University of Tokyo in 1991, and received his Ph.D. from Graduate School of Pharmaceutical Sciences, The University of Tokyo in 1996. He joined Otsuka Pharmaceutical Co. in 1996 and then The Scripps Research Institute as a Postdoctoral fellow in 1997. In 1999, he returned to Graduate School of Pharmaceutical Sciences, The University of Tokyo as an Assistant Professor. He moved to Department of Chemistry, Graduate School of Engineering Science, Osaka University as an Associate Professor in 2005. He has been a Full Professor from 2010 and a Distinguished Professor from 2021 at Graduate School of Pharmaceutical Sciences, Kyushu University. He has been Principal Investigator of Grant-in-Aid for Transformative Research Areas “Digitalization-driven Transformative Organic Synthesis (Digi-TOS)”. His research interests include asymmetric catalysis, green & sustainable chemistry, natural product synthesis, and medicinal chemistry. He is a member of the Pharmaceutical Society of Japan (PSJ), the Society of Synthetic Organic Chemistry Japan (SSOCJ), the American Chemical Society (ACS), The Japanese Society of Process Chemistry (JSPC), Kinka Chemical Society Japan, the Chemical Society of Japan (CSJ), and Catalysis Society of Japan.
Wu Jie, National University of Singapore
Title: Towards On-Demand Synthesis of Organic Small Molecules via Advanced Flow Technologies
Dr. Wu Jie finished his undergraduate study at Beijing Normal University in 2006. In 2012, he earned his Ph.D degree under the supervision of Prof. James Panek in the Department of Chemistry at Boston University. His PhD thesis was Total Synthesis of (-)-Virginiamycin M2 and Chiral Organosilane Based Sequential Transformations to Access Polycyclic Scaffolds. After that, he was a postdoctoral researcher in the Department of Chemistry and Chemical Engineering at MIT, working with Prof. Timothy Jamison and Prof. Alan Hatton. Since July 2015, Jie has been appointed as an assistant professor at National University of Singapore in the Chemistry Department. He also serves as NUS chemistry MSc Program Director.
Dong-Pyo Kim, POSTECH
Title: AI-assisted Auto-Manufacturing of Biopharmaceuticals in Flow
Prof. Kim is a Yonsan-chaired professor of POSTECH Chemical Engineering as a director of Center for Intelligent Microprocess of Pharmaceutical Synthesis. He obtained a Ph.D. in chemistry, a post-doctor in materials engineering, and worked at national lab and university side for over 30 years in total. His flow chemistry focuses on various platforms and processes for scale-up production, auto-manufacturing of API and DDS. He received an Excellent Chemist award in 2017 (KCS), POSTECHIAN in 2016, a Scientist of the Month in 2016, and a Henry McGee Lecturer in 2021 at Virginia State Univ.
Marcus Baumann, University College Dublin
Title:
After graduating from Philipps-University Marburg Marcus Baumann moved to Cambridge for his PhD with Prof. Steven Ley where he focused on the development of new continuous flow approaches towards important organic transformations and selected natural products. This was followed by a postdoctoral position at University of California Irvine, USA, then he took up a postdoctoral position with Prof. Ian R. Baxendale at the University of Durham, where he combined his interests in continuous flow technology and the synthesis of bioactive target molecules. In 2017 he joined University College Dublin as an Assistant Professor in Continuous Flow Chemistry where he focused on new continuous flow methods exploiting photochemistry, biocatalysis and high-energy processes, and was promoted to Associate Professor in March 2023.
Toshikazu Hakogi, Shionogi Pharma Co., Ltd.
Title:
Toshikazu Hakogi received his master degree in chemistry and PhD from Kwansei Gakuin University under supervision of Prof. Shigeo Katsumura on the area of natural product synthesis. He started his industrial career on the area of process chemistry with Shionogi Co. Ltd. In 2004 and he was seconded to Shionogi Pharma Co. Ltd., in 2019. At present he is a Group Leader of Continuous production technology department in Shionogi Pharma Co. Ltd. In Japan. His research interest includes development of new methodologies to access continuous reaction and crystallization to forward fully continuous process from starting materials to products.
Luo Guangsheng, Tsinghua University
Title:
Thomas Wirth, Cardiff University
Title: Opportunities for Iodine Reagents in Flow Synthesis
Thomas Wirth is professor of organic chemistry at Cardiff University. After studying chemistry in Bonn, he obtained his PhD and at the Technical University of Berlin. After a postdoctoral stay at Kyoto University, he started his independent research at the University of Basel in 1994, before taking up his current position at Cardiff University in 2000. He was invited as a visiting professor to several places. Thomas Wirth was awarded the Werner-Prize from the New Swiss Chemical Society (2000), the Wolfson Research Merit Award from the Royal Society and the Bader Award from the Royal Society of Chemistry (2016). In 2016 he was elected as a fellow of The Learned Society of Wales. His main interests of research concern stereoselective electrophilic reactions, oxidative transformations with hypervalent iodine reagents including mechanistic investigations and electrochemical synthesis performed in microreactors.
Yoshihiro Kon, AIST
Title:
Claudio Battilocchio, Syngenta
Title:
Claudio graduated from La Sapienza in Medicinal Chemistry in 2008 and obtained his PhD in Pharmaceutical Sciences in 2012. He spent ca 7 years at the University of Cambridge working in the field of Flow Chemistry with Prof Steve Ley, in collaboration with several companies. Claudio received his PhD in February 2013 at “Sapienza” University of Rome. In January 2021, Claudio took up a temporary assignment in the Development Department at Syngenta, in Muenchwilen, working on two Development projects for crop protection candidates. In September 2021, he returned to Syngenta Stein, where he took up the role of Chemistry Automation Lead, in Process Research, and being involved in operational leadership and automation & digital initiatives. Claudio was appointed to the position of Digital and Automation Prototype, Transformation Lead for CPR in 2023. As of January 2024, he has taken up the position of Digital automation & IoT lead for R&D.
Joji Tsurumoto, iFactory
Title: The reality and future vision of fully automated continuous production of pharmaceuticals created by iFactory
My name is Joji Tsurumoto, and I manage business development at iFactory Inc. After receiving a pharmacist’s license, I received my master’s degree in organic chemistry from Nagasaki University. From 2006 to 2019, I was in charge of process development for API of small molecules at Mitsubishi Tanabe Pharma Corporation. After that, I was fascinated by the possibilities of continuous manufacturing technologies, I contributed to the development of the continuous manufacturing system “iFactory” at Takasago Chemical Corporation for four years. During that time, I received several awards for open innovation and engineering.
Tomohiro Ichitsuka, AIST
Title:
Biography
Christian Hornung, CSIRO
Title:
Biography:
Amol A. Kulkarni, CSIR-National Chemical Laboratory
Title:
Biography:
Fener Chen, Fudan University
Title:
Biography:
Flash Presentations – Industrial Session
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